| | | | | |
| Live | Randomisation | ACESATHOME | ISRCTN58902324 | Pending | N/A |
| Alternative CErvical Screening – At Home The overall aim is to provide evidence for urine-based cervical screening in current non-attenders of cervical screening, including preference of screening methods and the feasibility of at-home testing for the future. |
| Completed pending | Randomisation | ACLIMAGE | NCT04958655 | Pending | N/A |
| Estimating the acute impact of competing mental imagery on craving in alcohol use disorder. |
| Archived | Randomisation | ACTfR | ISRCTN68540929 | Published | N/A |
| ACT for Recovery |
| Archived | Randomisation | ACTIB | ISRCTN44427879 | Published | N/A |
| Assessing Cognitive behavioural Therapy in Irritable Bowel |
| Archived | Randomisation | ACTMUS | NCT02810028 | Published | N/A |
| Acceptance and Commitment Therapy for Muscle Disease |
| Archived | Randomisation | ADAPT | ISRCTN15090567 | Published | N/A |
| The role of anti-IgE (omalizumab) in the management of severe recalcitrant paediatric atopic eczema |
| Completed pending | Randomisation | ADEPT | ISRCTN81203286 | Published | N/A |
| Optimising psychological treatment for Anxiety DisordErs in Pregnancy: a feasibility treatment trial |
| Completed pending | Randomisation | ADeSS | NCT03628027 | Published | N/A |
| The Antidepressant Advisor: A decision support system for UK primary care – a feasibility study |
| Archived | Randomisation | ADVANCE | ISRCTN79435190 | Published | N/A |
| Feasibility and acceptability of a randomised controlled trial of an integrated group intervention to reduce intimate partner violence perpetration among men receiving treatment for substance use |
| Completed | EDC | ADVANCE | ISRCTN66619273 | Published | N/A |
| Feasibility of adapting and delivering the ADVANCE technology-enabled intervention to reduce intimate partner abuse by men receiving substance use treatment |
| Archived-Closed | Randomisation | ADVANCE_Full | ISRCTN66619273 | Pending | N/A |
| A randomised controlled trial of the ADVANCE integrated group intervention to reduce intimate partner abuse
perpetration by men receiving treatment for substance use |
| Live | EDC | ADVANCE-D | ISRCTN95692133 | | N/A |
| A UK multi-centre cluster randomised control trial, with internal pilot, of the ADVANCE-Digitally supported perpetrator intervention compared to community justice offender management (1:1), to reduce intimate partner violence (IPV), for men convicted of IPV who misuse substances (ADVANCE-D trial) |
| Archived | Randomisation | AerosureCF | NCT01923753 | Pending | N/A |
| A short – term comparative study of Aerosure for airway clearance in patients with cystic fibrosis |
| Archived | Randomisation | AerosureCOPD | NCT02007590 | Pending | N/A |
| Does high-frequency airflow oscillation, delivered using Aerosure, increase exercise capacity in severe chronic obstructive pulmonary disease? |
| Live | EDC | ALTO | ISRCTN12680338 | Pending | N/A |
| Arthritis prevention in the pre-clinical phase of rheumatoid arthritis with abatacept long-term outcome study |
| Abandoned | Randomisation | AMBIC | N/A | Abandoned | N/A |
| A randomised controlled trial of community brief mentalization based therapy compared to psychiatric admission in borderline personality disorder : a study of clinical outcome and cost difference |
| Archived | Randomisation | AMBITION | ISRCTN37625384 | Published | N/A |
| Mindfulness-based crisis interventions (MBCI) for psychosis within acute inpatient psychiatric settings: a feasibility randomised controlled trial |
| Archived | Randomisation | AneurysmCare | ISRCTN65746249 | Published | N/A |
| Aneurysm Care Pilot Study |
| Completed Pending | Randomisation | APIPPRA_NETHERLANDS | ISRCTN46017566 | Published | N/A |
| Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept (APIPPRA) |
| Completed Pending | Randomisation | APIPPRA_UK | ISRCTN46017566 | Published | N/A |
| Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept (APIPPRA) |
| Completed pending | Randomisation | APRICOT | 2015-003600-23 | Published | N/A |
| Treatment of pustular psoriasis with the IL-1 receptor antagonist anakinra: a randomised, placebo controlled trial and associated mechanistic studies |
| Completed Pending | Randomisation | APRIL | NCT05865249 | Pending | N/A |
| Artificial intelligence in PRImary Care spirometry pathways for diagnosis of Lung Disease (APRIL) |
| Archived | Randomisation | ARC | ISRCTN69313751 | Published | N/A |
| The Addiction Recovery Clinic (ARC): personalised behavioural intervention for opioid use disorder |
| Live | Randomisation | ARIA | ISRCTN13832085 | Pending | N/A |
| A randomised controlled trial to assess the clinical-, technical- and cost-effectiveness of a cloud-based, ARtificially Intelligent image fusion system in comparison to standard treatment to guide endovascular Aortic aneurysm repair |
| Completed pending | Randomisation | ASCOT | ISRCTN30012492 | Published | N/A |
| A phase 3 multi-center double masked randomised controlled trial of adjunctive intraocular and periocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing viteroretinal surgery for open globe trauma |
| Archived | Randomisation | ASPI | ISRCTN57199411 | Published | N/A |
| Anxiety Symptoms Prevention Investigation (ASPI): Transmission of anxiety from parent to child ? investigating cognitive-behavioural processes, developing and piloting a brief preventative intervention |
| Completed pending | Randomisation | ATLANTIS | ISRCTN77257074 | Pending | N/A |
| AnTiconvuLsant AugmeNtation Trial In Schizophrenia: a randomised, pragmatic double-blind, placebo-controlled trial to assess the effectiveness of valproate augmentation of antipsychotic treatment in patients with residual psychotic symptoms |
| Archived | Randomisation | ATOM | ISRCTN25691213 | Abandoned | N/A |
| Atomoxetine for attention deficit hyperactivity disorder (ADHD) in children with special educational needs |
| Live | Randomisation | ATTEND | ISRCTN17687131 | Pending | N/A |
| ATTEND: Adolescents and carers using mindfulness Therapy To END depression |
| Live | Randomisation | ATTENS | ISRCTN82129325 | Pending | N/A |
| A multi-centre, blinded, randomized, parallel-group, phase IIb study to compare the efficacy of real versus sham Trigeminal Nerve Stimulation (TNS) on symptoms in youth with Attention-Deficit/Hyperactivity Disorder |
| Archived | Randomisation | AVATAR | ISRCTN65314790 | Published | N/A |
| Reducing the frequency and severity of auditory hallucinations: a randomised clinical trial of a novel Audio-Visual Assisted Therapy Aid for Refractory auditory hallucinations (AVATAR) compared to supportive counselling |
| Completed pending | Randomisation | AVATAR2 | ISRCTN55682735 | Pending | N/A |
| Optimising AVATAR therapy for distressing voices: a multi-centre randomised controlled trial |
| Live | Randomisation | Aware | ISRCTN17631228 | Pending | N/A |
| Promoting mental health and wellbeing in schools: examining Youth Aware of Mental Health (YAM) and the Mental Health & High School Curriculum Guide (The Guide) in English secondary schools |
| Live | Randomisation | BalanceACT | NCT06231238 | Pending | N/A |
| A randomised controlled trial assessing the efficacy of balance acceptance and commitment therapy (ACT) for Long COVID |
| Archived | Randomisation | BalancingACT | ISRCTN73327972 | Pending | N/A |
| Balancing ACT: Evaluating the effectiveness of psychoeducation and Acceptance and Commitment Therapy (ACT) groups for people with bipolar disorder. |
| Completed pending | Randomisation | BapEFL | ISRCTN10950727 | Pending | N/A |
| Feasibility Randomised Controlled Trial of Being a Parent- Enjoying Family Life: a specialised intervention for parents with significant emotional and interpersonal needs. |
| Completed pending | Randomisation | BARILIFESTYLE | NCT03214471 | Published | N/A |
| Evaluation of the effect of a post-surgery lifestyle intervention compared to usual care upon post-surgery weight loss and changes in body composition, physical activity levels and health-related quality of life in the first year following bariatric surgery |
| Live | Randomisation | BEACON | ISRCTN11056540 | Pending | N/A |
| Best Systemic Treatments for Adults with Atopic Eczema over the Long Term |
| Archived | Randomisation | BeMind | ISRCTN52684820 | Published | N/A |
| A comparison to two types of group behaviour therapy for obsessive compulsive disorder: A pilot randomised controlled trial of behaviour therapy and mindfulness-based behaviour therapy for OCD |
| Live | EDC | BESST | ISRCTN90912799 | Published | N/A |
| Brief Educational workshops in Secondary Schools Trial: a multi-centre cluster randomised controlled trial of self-referral psychological stress workshops in schools for depression and anxiety in 16-18 year-olds. |
| Completed pending | Randomisation | BIORAPAIN | 2019-004468-23 | Published | N/A |
| Comparison of abatacept with tumor necrosis factor inhibitors in the treatment of rheumatoid arthritis pain: A phase IV trial |
| Archived | Randomisation | BISCORT | ISRCTN70836126 | Pending | N/A |
| Does a breathlessness intervention service (‘CBIS’) reduce stress significantly more than usual care in breathless patients with advanced non-malignant disease and their carers? A phase II feasibility study |
| Migrated | Randomisation | BOPPP | ISRCTN10324656 | Pending | N/A |
| Beta-blockers or placebo for primary prophylaxis of oesophageal varices.
A blinded, multi-centre, clinical effectiveness and cost-effectiveness randomised controlled trial. |
| Live | Randomisation | BOPPP | ISRCTN10324656 | Pending | N/A |
| Beta-blockers or placebo for primary prophylaxis of oesophageal varices.
A blinded, multi-centre, clinical effectiveness and cost-effectiveness randomised controlled trial. |
| Completed pending | Randomisation | BreathePlus | ISRCTN13051922 | Published | N/A |
| Breathe Plus: Feasibility trial of a comprehensive geriatric assessment for people with COPD and frailty attending pulmonary rehabilitation |
| Archived | Randomisation | BREATHLESSNESS | NCT01165034 | Published | N/A |
| Development of King’s College Hospital Breathlessness Service |
| Archived | Randomisation | BReF | ISRCTN91238019 | Published | N/A |
| Cognitive Behavioural Therapy (CBT) for Renal Fatigue (BReF): A feasibility pilot randomised-controlled trial of CBT for the management of fatigue in haemodialysis (HD) patients. |
| Completed pending | Randomisation | CAcTUS | NCT03808441 | Pending | N/A |
| A parallel arm, biomarker driven, phase II feasibility trial to determine the role of circulating tumour DNA in guiding a switch between targeted therapy and immune therapy in patients with advanced cutaneous melanoma |
| Completed pending | Randomisation | CADMUS | NCT02712684 | Pending | N/A |
| Multi-parametric Ultrasound targeted biopsies compared to Multiparametric MRI targeted biopsies in the diagnosis of clinically significant prostate cancer |
| Live | Randomisation | CaFI | ISRCTN12622538 | Pending | N/A |
| The effect on relapse of Culturally-adapted Family Intervention (CaFI) compared to usual care among Sub-Saharan African & Caribbean people diagnosed with psychosis in the UK: A Randomised Controlled Trial |
| Completed pending | Randomisation | CALLME | ISRCTN71271888 | Pending | N/A |
| Care Augmentation by Location-Linked Messaging |
| Archived-Closed | Randomisation | CANPDP | 2019-003623-37 | Pending | N/A |
| Cannabidiol for Parkinson’s Disease Psychosis |
| Archived | Randomisation | CANWALK | ISRCTN42072606 | Published | N/A |
| A study to assess the acceptability and feasibility of a walking intervention for people with recurrent or metastatic cancer |
| Archived | Randomisation | CAREER | ISRCTN17767032 | Published | N/A |
| CAReer management to improve Education, Employment and Retention for people with anxiety and depression |
| Archived | Randomisation | CASAAF | ISRCTN18250790 | Published | N/A |
| Catheter Ablation vs. Thoracoscopic Surgical Ablation in Long-Standing Persistent Atrial Fibrillation |
| Archived | Randomisation | CASIS | ISRCTN06149665 | Published | N/A |
| A randomised pragmatic trial comparing the cost effectiveness of supplementing standard care with an intervention for carers (Carers Assessment, Skills and Information Sharing [CASIS]) of people with eating disorders |
| Archived | Randomisation | CBDVR2 | ISRCTN11082858 | Pending | N/A |
| The effect of CBD on paranoid cognitions in humans |
| Archived | Randomisation | CBMpa | ISRCTN90749868 | Published | N/A |
| Cognitive Bias Modification for Paranoia |
| Archived | Randomisation | CIAOII | ISRCTN16827947 | Published | N/A |
| Randomised controlled trial of the short term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention deficit hyperactivity disorder |
| Completed pending | Randomisation | CICADA | ISRCTN48328178 | Pending | N/A |
| Inhibiting white blood cell function as a new way to treat coronary heart disease |
| Archived | Randomisation | CIIC | NCT03656653 | Published | N/A |
| Clinical Study of Imagery-based Coping for Cocaine Use Disorder |
| Completed | Collaboration | Cindy Cooper (CI) | N/A | Completed | N/A |
| Learning from COVID-19 related trial adaptations to inform efficient trial design-a sequential mixed methods study |
| Archived | Randomisation | CLARITY | ISRCTN32207582 | Published | N/A |
| Clinical Efficacy and Mechanistic Evaluation of Aflibercept for Proliferative Diabetic Retinopathy (CLARITY). A Multicentre Phase IIb Randomised Active-Controlled Clinical trial. |
| Archived | Randomisation | CLASSIC | ISRCTN26634837 | Published | N/A |
| Can ‘self-confidence workshops’ for depression help the implementation of the NICE Guidelines? |
| Live | Randomisation | CLEAR | ISRCTN37176025 | Pending | N/A |
| CLOZAPINE IN EARLY PSYCHOSIS (CLEAR): A MULTI-CENTRE, RANDOMISED CONTROLLED TRIAL OF CLOZAPINE FOR YOUNG PEOPLE WITH TREATMENT RESISTANT PSYCHOSIS IN REAL WORLD SETTINGS |
| Live | EDC | CLEMPTS | ISRCTN10416636 | Pending | N/A |
| Closed-Loop Electronic stimulation - Mechanomyogram sensor system for Passive tremor Suppression treatment (CLEMPTS) |
| Archived | Randomisation | CLEOPATRA | ISRCTN85596558 | Published | N/A |
| The clinical efficacy and safety of light-masks at preventing dark adaptation in the treatment of early diabetic macular oedema: A Multicentre Phase III Randomised Controlled Single-Masked Clinical trial |
| Archived | Randomisation | CLIP | ISRCTN18067579 | Pending | N/A |
| Pharmacokinetic study of a novel lipid formulation of cannabidiol (CBD) |
| Archived | Therapy Rating | CODES | ISRCTN05681227 | Published | N/A |
| COgnitive behavioural therapy vs standardised medical care for adults with Dissociative non-Epileptic Seizures: A multicentre randomised controlled trial |
| Archived | Randomisation | CODES | ISRCTN05681227 | Published | N/A |
| COgnitive behavioural therapy vs standardised medical care for adults with Dissociative non-Epileptic Seizures: A multicentre randomised controlled trial |
| Live | Randomisation | CommonGround | NCT06222346 | Pending | N/A |
| Online peer support in long-term conditions: A feasibility randomised controlled trial. |
| Completed Pending | Randomisation | COMPASS | ISRCTN21454676 | Pending | N/A |
| Communication-centred Parent-mediated treatment for Autism Spectrum Disorder in South Asia |
| Archived | Therapy Rating | CONMAN | ISRCTN72794493 | Published | N/A |
| Contingency management targeting increased completion of hepatitis B (Hep B) vaccination amongst people in treatment for heroin dependence |
| Archived | Randomisation | CONMAN | ISRCTN72794493 | Published | N/A |
| Contingency management targeting increased completion of hepatitis B (Hep B) vaccination amongst people in treatment for heroin dependence |
| Archived | Randomisation | CONVINCE | NCT02543021 | Published | N/A |
| A study to assess the feasibility and patient acceptability of a randomised, crossover design to compare virtual vs conventional chromoendoscopy for the detection of dysplasia in colitis |
| Completed pending | Randomisation | COPe | ISRCTN89563420 | Published | N/A |
| EFFIP (E-support for Families and Friends of Individuals affected by Psychosis): A randomised controlled trial of a co-produced online intervention for carers |
| Completed | EDC | COPE_Hewitt | N/A | Published | N/A |
| The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study |
| Archived | Randomisation | CORAL | NCT01379014 | Published | N/A |
| COnceal or ReveAL |
| Archived | Randomisation | CRAVING | ISRCTN16462783 | Published | N/A |
| Pilot Feasibility Study of Cognitive Control in Cocaine Dependence |
| Archived | Randomisation | CRiB | ISRCTN32290525 | Published | N/A |
| Cognitive Remediation in Bipolar disorder: a feasibility study |
| Live | Randomisation | CRIB2 | ISRCTN10362331 | Pending | N/A |
| Cognitive Remediation in Bipolar (CRiB2): a randomised trial assessing efficacy and mechanisms of cognitive remediation therapy compared with usual care |
| Archived | Randomisation | CRIMSON | ISRCTN11501328 | Published | N/A |
| CRIMSON Study: Randomised controlled trial (RCT) of Joint Crisis Plans to reduce compulsory treatment of people with psychosis |
| Archived | Randomisation | CRISP | ISRCTN98067793 | Published | N/A |
| Critical time intervention for severely mentally ill released prisoners |
| Archived | Randomisation | CRUNCH | ISRCTN33260236 | Published | N/A |
| Development of a randomized controlled trial to increase cereal fibre intake to reduce insulin resistance in children. |
| Completed pending | Randomisation | CTARSWIFT | ISRCTN12813363 | Pending | N/A |
| Chin Tuck Against Resistance with Feedback: Swallowing Rehabilitation in Frail Older People - A feasibility study |
| Archived | Randomisation | CUES | ISRCTN13766770 | Published | N/A |
| Coping with Unusual Experiences in Children Study |
| Live | Collaboration | Cues-ED | ISRCTN11445338 | Pending | N/A |
| A cluster randomised, 16-week, parallel-group multicentre trial to compare the effectiveness of a digital school-based cognitive behavioural resilience/wellbeing-building intervention (CUES for schools) targeting emotional and behavioural problems in vulnerable year 4 primary school children in whole classes, compared to the usual school curriculum. |
| Archived | Randomisation | CUESPLUS | ISRCTN21802136 | Pending | N/A |
| Coping with Unusual ExperienceS for 12-18 (CUES+) |
| Completed pending | Randomisation | DAISIES | ISRCTN10166784 | Published | N/A |
| A Randomised Controlled Multi-Centre Open-Label Parallel Group Non-Inferiority Trial of the Clinical Effectiveness, Acceptability and Cost-Effectiveness of a ‘Stepping into Day Treatment’ Approach versus Inpatient Treatment as Usual for Anorexia Nervosa in Adult Specialist Eating Disorder Services (DAISIES Trial) |
| Archived | Randomisation | DATES | ISRCTN10342151 | Pending | N/A |
| Diabetes And Telecommunications Study to support self-management for people with type 2 diabetes: a randomized controlled trial(The DATES trial) |
| Archived | Randomisation | DAWN | ISRCTN83768230 | Published | N/A |
| Depression: a trial of antenatal guided self help for women |
| Live | Collaboration | DEEP | N/A | Pending | N/A |
| Emerging evidence on the impact of COVID-19 on mental health services and health inequalities in highly deprived communities. |
| Archived | Randomisation | DFEND | 2014-002639-32 | Published | N/A |
| A randomised, double-blind, placebo-controlled, parallel-group trial of Vitamin D supplementation compared to placebo in people presenting with their First Episode of psychosis Neuroprotection Design (DFEND) |
| Archived | Randomisation | DiabetesStopWatch | NCT02919397 | Published | N/A |
| Motivational Instant Messaging and E-diabetes Prevention Programme for High Risk of Type 2 Diabetes
|
| Completed pending | Randomisation | DIMES | ISRCTN13339678 | Published | N/A |
| Insulin intervention development for people with type 2 diabetes |
| Archived | Randomisation | DISCOVER | ISRCTN88636606 | Published | N/A |
| Early intervention for depression and anxiety in 16-18 year olds: a feasibility trial of open-access psychological workshops in schools
|
| Completed pending | Registration | DISKO | ISRCTN96920058 | Pending | N/A |
| The Effect of Denosumab on Pain and Bone Marrow Lesions in Symptomatic Knee Osteoarthritis: A Randomised Double Blind Placebo Controlled Clinical Trial |
| Live | EDC | EAM | 2019-000712-29 | Pending | N/A |
| Clinical safety study of a novel Esmolol/Adenosine/Magnesium (EAM) cardioplegia concentrate |
| Archived | Randomisation | ECHO | ISRCTN83003225 | Published | N/A |
| Expert Carers Helping Others
|
| Archived | Randomisation | ECLIPSE | ISRCTN14678860 | Published | N/A |
| ECLIPSE Study 9: Building resilience and recovery through enhancing cognition and quality |